Learning-mediated plasticity in cortical feedback projections to the olfactory bulb
To reliably encode information about the environment, neurons must modify their activity profiles and even connectivity to accurately interpret complex stimuli. Cortical feedback projections to the olfactory bulb are uniquely positioned at the interface between detection-based processing that is driven by sensory input and analytical processing occurring in the piriform cortex. This makes these projections an ideal target to study how learning reshapes neuronal activity profiles. We have developed an approach that will allow for a comprehensive analysis of the axonal activity of principal neurons in the piriform cortex, while mice learn a task requiring them to identify a specific odor embedded in complex mixtures.
Our technical approach uses animal behavior, patch-clamp electrophysiology, and in vivo imaging to study these cells and circuits.
Information coding in olfactory sensory neurons